2,3-Dinor 11 Beta-Prostaglandin F2 Alpha, Random, Urine BWFH Order Code: 23BPR 
    Site
 
BWFH
 
    System
 
SUNQUEST LAB
 
    Epic Lab Code
 
LAB45289
 
    Local Code
 
23BPR
 
    Specimen
 
RANDOM URINE
 
    Container
 
Random urine
 
    Collection Instructions
 
Patient Preparation: Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAID) may have decreased concentrations of prostaglandin F2 alpha. If possible, discontinue for 2 weeks or 72 hours, respectively, prior to collecting a specimen.

Collection Instructions: Collect a random urine specimen.
 
    Testing Schedule
 
Accepted 24 hours a day. Sent out routinely twice a day, Monday thru Friday and routinely once a day on Saturday and Sunday.
 
    Turnaround Time
 
PERFORMED: Monday, Thursday

3  to 7 days
 
    Order Message
 
Although a random urine collection is acceptable, the preferred specimen for 2,3-dinor-11beta-prostaglandin F2 alpha analysis is a 24-hour urine collection; order 23BPT / 2,3-Dinor-11 Beta-Prostaglandin F2 Alpha, 24 Hour, Urine.

If ordering this test with NMHR / N-Methylhistamine, Random, Urine, both tests must be ordered under different order numbers. They cannot share an order number.
 
    Test Usage
 
Screening for mast cell activation disorders including systemic mastocytosis using random urine specimens


2,3-Dinor-11beta-prostaglandin F2 alpha (2,3 BPG) is elevated in the urine of patients with systemic mastocytosis (SM).

This test should be used as a screening test for SM.

When 2,3 BPG is used in combination with urinary leukotriene E4 and N-methyl histamine, the sensitivity for SM detection increases to 90%.
 
    Result Interpretation
 
Elevated urine 2,3-dinor-11beta-prostaglandin F2 alpha is consistent with systemic mastocytosis.

CAUTIONS:
Elevated levels of 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG) in urine are not specific for systemic mast cell disease and may be found in patients with angioedema, diffuse urticaria, or myeloproliferative diseases in the absence of diffuse mast cell proliferation.

Systemic mast cell disease is a heterogeneous disease, and some patients may not have elevated 2,3 BPG in urine.
 
    Additional Information
 
Additional information from reference laboratory
 
    Reference Range
 
<1802 pg/mg creatinine
 
    Department
 
SENDOUTS
 
    Reference Laboratory
 
MAYO MEDICAL LABORATORY
 
    Performing Laboratory
 
Mayo - Rochester
 
    Methodology
 
R23BP: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
CRETR: Enzymatic Colorimetric Assay
 
    Rejection Criteria
 
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability
 
    Send Out
 
Yes
 
    Stability
 
Refrigerated (preferred) 14 days 
Frozen 30 days 
Ambient 8 hours
 
    Transport Temperature
 
Refrigerated
 
    Reference Lab Code
 
23BPR
 
    CPT Code
 
84150, 82570
 
    Last Update
 
8/16/2021 14:34:23