MGH

SUNQUEST LAB

LAB45144

MHYPC

BLOOD

Blue top tube, Na Citrate, 3 ml

REQUIRES 4 blue top tubes and ONE GOLD TOP TUBE.

Attempt to draw four to five 1.8 mL blue top tubes; must be drawn to fill line on tube. Must draw one gold top tube, minimum 2mL whole blood.

1-7 days

The hypercoagulation panel consists of Protein C activity (if low protein C antigen and factor VII), Protein S activity (if low, protein S free antigen, factor VIII and fibrinogen), antithrombin III, activated protein C resistance (if abnormal, specific factor V Leiden DNA test), lupus anticoagulant, anticardiolipin ab IgG IgM, anti-B2 glycoprotein ab IgG IgM, Prothrombin 20210 gene mutation, dilute Russell viper venom screen, PT, PTT. 
Protein C and protein S cannot be performed if the patient is on coumadin, because their levels will be decreased. 
Antithrombin, APCR, protein S, lupus anticoagulant testing cannot be performed if the patient is on Argatroban, dabigatran, bivalirudin as these can cause erroneous results.
Rivaroxaban, apixaban, edoxaban may give erroneous results with the APCR, proten S and lupus anticoagulant testing.  
Please call the laboratory to discuss options if the patient is on these anticoagulants or if there is a special situation. 
Please indicate in the order comment if the patient is currently on anticoagulants and list anticoagulant(s).  Please also indicate in the order comment if the patient has experienced recent/current thrombosis or bleeding.

Please note: as of 4/1/25, the tube type for Anticardiolipin Antibodies and Beta-2 Glycoprotein, which are part of this panel, has been updated to GOLD.

Evaluate patients with symptoms of hypercoagulation.

Prothrombin Time
(sec)
0 - 4 days                    10.1-16.0
4 days  - 18 days             10.0-15.4
18 days  - 2 months           10.0-14.4
2 months  - 6 months          10.0-14.3
6 months and up               11.0-14.0

FUNCTIONAL PROTEIN C
(%)
0 - 4 days                    17-54
4 days  - 18 days             20-65
18 days  - 2 months           21-66
2 months  - 5 months          28-81
5 months  - 8 months          37-82
8 months and up               70-140

ANTITHROMBIN III
(%)
0 - 4 days                    39-88
4 days  - 18 days             41-94
18 days  - 2 months           48-109
2 months  - 6 months          73-122
6 months and up               80-130

APC-RESISTANCE SCRN.
All Ages                      >2.0

APC-1
(sec)
All Ages                      20-47

INR
0 - 4 days                    0.8-1.3
4 days  - 18 days             0.8-1.2
18 days  - 2 months           0.8-1.1
2 months  - 6 months          0.8-1.1
6 months and up               0.9-1.1

PTT-LA
All Ages                      Negative for a lupus anticoagulant.

FUNCTIONAL PROTEIN S
(%)
0 - 4 days                    12-61
4 days  - 18 days             22-79
18 days  - 2 months           33-94
2 months  - 5 months          54-119
5 months  - 8 months          55-120
8 months and up               70-140

aPTT
(sec)
0 - 4 days                    25.3-48.3
4 days  - 18 days             22.1-54.0
18 days  - 2 months           25.0-49.2
2 months  - 5 months          23.0-44.1
5 months  - 7 months          22.1-37.0
7 months and up               22.0-35.0

MGH Special Coagulation Lab

$$$

No

4/1/2025 09:37:13